The 25 Most Valuable Comic Books From the 2000s
The 2000s were the modern indie and creator-owned boom, alongside a new wave of Marvel and DC characters who quickly jumped to screen. The decade’s keys include the debuts of Invincible, Rick Grimes, X-23, and Ahsoka Tano. Below are the most valuable key 2000s comics, ranked by current raw Near Mint (9.4) value and refreshed automatically from live market data.
Unlike the overproduced 90s, many 2000s keys came from smaller print runs — especially indie first issues — so the right books have appreciated sharply as their characters reached film, TV, and streaming.
| # | Comic | Key / First Appearance | NM Value |
|---|---|---|---|
| 1 | Invincible (2003) #1 | Invincible (Mark Grayson), Omni-Man, Deborah Grayson, Titan, William Clockwell, David Hiles, Atom Eve (cameo), Science Dog (cameo) | $2,935 |
| 2 | Zombie Tramp (2009) #1 | Zombie Tramp (Janey Belle) | $1,100 |
| 3 | The Walking Dead (2003) #1 | Sheriff Rick Grimes | $1,090 |
| 4 | Invincible (2003) #2 | Atom Eve (full), Allen The Alien (cameo), The Mauler Twins, Robot, Rex-Splode, Dupli-Kate | $525 |
| 5 | Spawn (1992) #174 | Gunslinger Spawn (full) | $460 |
| 6 | Invincible (2003) #5 | Allen The Alien (full) | $450 |
| 7 | NYX (2003) #3 | X-23 (Laura Kinney) | $405 |
| 8 | Invincible (2003) #19 | Nowhere Men (team), Battle Beast, Magnattack, Magmaniac, Tether Tyrant | $400 |
| 9 | Spider-Man: Noir (2008) #1 | Spider-Man Noir (Peter Parker) | $400 |
| 10 | Invincible (2003) #10 | Doc Seismic | $385 |
| 11 | Invincible (2003) #3 | The Flaxans | $350 |
| 12 | Invincible (2003) #9 | The Lizard League (team), Shrinking Ray, Monster Girl, Bulletproof (cameo) | $335 |
| 13 | Invincible (2003) #7 | Guardians Of The Globe (team), Bi-Plane, Kursk | $325 |
| 14 | Invincible (2003) #8 | Damien Darkblood, Amber Bennett, Elephant | $315 |
| 15 | Invincible (2003) #6 | Black Samson, Reanimen | $300 |
| 16 | Star Wars: The Clone Wars (2008) #1 | Ahsoka Tano, Captain Rex | $300 |
| 17 | The Walking Dead (2003) #3 | Dale, Carol, Sophia and Andrea | $230 |
| 18 | Teen Titans Go! (2003) #23 | Red X | $200 |
| 19 | Sonic The Hedgehog (1993) #98 | Shadow the Hedgehog, Rouge the Bat, Commander Brass (Hugo Brass), President of the United Federation | $200 |
| 20 | The Walking Dead (2003) #19 | Michonne | $185 |
| 21 | Adam: Legend Of The Blue Marvel (2009) #1 | Blue Marvel (Adam Brashear), Anti-Man (Conner Sims) | $175 |
| 22 | Invincible (2003) #44 | Anissa | $155 |
| 23 | Star Wars: Knights Of The Old Republic (2006) #9 | Darth Revan | $150 |
| 24 | Spawn (1992) #165 | Mandarin Spawn | $125 |
| 25 | Spawn (1992) #119 | Gunslinger Spawn (cameo), Hellspawn Army | $125 |
Values are raw Near Mint (9.4) estimates from live market data and change over time. Look up any comic's value.
The most valuable 2000s keys
Invincible #1 (2003) tops the decade — the debut of Robert Kirkman and Cory Walker’s Invincible and Omni-Man, whose hit animated series sent an already-scarce first issue soaring.
The Walking Dead #1 (2003) sits near the top — the first appearance of Rick Grimes and the launch of the franchise that defined the decade in comics and on television. Marvel’s screen pipeline drives much of the rest: NYX #3 (2004) is the first X-23 (Laura Kinney), and Star Wars: The Clone Wars #1 (2008) the first Ahsoka Tano.
Image’s creator-owned era dominates the list. Beyond the first issue, early Invincible chapters carry real value for their own debuts — the first full Atom Eve, Allen the Alien, and the Guardians of the Globe among them — a reminder that in this era a scarce indie run can be worth more than a stack of mainstream keys.
What makes a 2000s comic valuable
Modern Age value is driven by screen adaptations more than any prior era. When a 2000s character debuts in a film or streaming series, demand for their first appearance can spike overnight — which is why the values here track the live market. Indie first issues, often printed in modest runs, reward that demand the most, since supply is limited.
Condition still matters, though 2000s books survive in higher grades than older eras. Raw Near Mint (9.4) is the benchmark shown here; for the top keys, high-grade professionally graded (CGC) copies carry meaningful premiums.
How these values are calculated
The figures here are raw Near Mint (9.4) values derived from recent sales and refreshed automatically — not a fixed annual guide. Click any issue for its full condition-by-grade breakdown, graded (CGC) values, and price history. Values are estimates and the market moves, so treat them as a current snapshot rather than a formal appraisal.
Frequently Asked Questions
What is the most valuable comic book from the 2000s?
As of August 2026, Invincible (2003) #1 (first appearance of Invincible (Mark Grayson), Omni-Man, Deborah Grayson, Titan, William Clockwell, David Hiles, Atom Eve (cameo), Science Dog (cameo)) is the most valuable, with a raw Near Mint value around $2,935.
Why is Invincible #1 so valuable?
It’s the first appearance of Invincible and Omni-Man (2003). Its modest initial print run plus the success of the animated series have made this indie first issue the decade’s most valuable key.
Why is The Walking Dead #1 valuable?
It’s the first appearance of Rick Grimes (2003) and the start of one of the best-selling comic franchises ever. The hit TV series and its scarce early print run keep demand high.
Are 2000s comic books worth anything?
Many common issues are inexpensive, but key first appearances — especially indie first issues with smaller print runs — can be very valuable, ranging from hundreds to thousands of dollars in Near Mint.
Are graded (CGC) 2000s comics worth more than raw copies?
For the top keys, yes — high-grade CGC copies command premiums, though the gap is smaller than for older, scarcer eras.
How often do these values update?
Automatically, from live market data — so this list reflects the current market, not a static annual guide.